Manuscript qualityWhy unclear questions, design limitations, outcome problems, analytical weaknesses, incomplete reporting, unsupported conclusions, and poor reproducibility attract major reviewer concern.
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InterpretationA structured approach to causal language, effect magnitude, precision, multiplicity, subgroup findings, missing data, limitations, and generalizability.
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Methods & statisticsFrom the research question and estimand to model assumptions, missing data, effect estimates, uncertainty, diagnostics, sensitivity analyses, and reproducibility.
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RevisionBuild a complete response matrix, quote each comment accurately, state the action taken, locate every change, and justify disagreements professionally.
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