Research question and estimand
Population, exposure or intervention, comparator, outcomes, time horizon, and the effect the analysis is intended to estimate.
Study design, methods & statistics
Focused technical review for protocols, analysis plans, datasets, results, or manuscripts requiring careful assessment of design, bias, statistical methods, reporting, and interpretation.
Technical review
A checklist cannot replace judgment. The review is adapted to the research question, design, outcome structure, data limitations, and intended inference.
Population, exposure or intervention, comparator, outcomes, time horizon, and the effect the analysis is intended to estimate.
Selection, measurement, confounding, clustering, repeated observations, missingness, temporality, and other design-specific threats.
Model choice, assumptions, variable handling, effect measures, uncertainty, multiplicity, sensitivity analyses, and internal consistency.
Denominators, descriptive summaries, effect estimates, confidence intervals, exact methods, software, diagnostics, and reproducibility information.
Alignment of conclusions with the design, analysis, precision, limitations, and distinction between association, prediction, and causation.
Defined output
One focused report addressing the technical questions included in the confirmed scope.
Prioritized findings on design, analysis, assumptions, reporting, and interpretation.
Specific recommendations distinguishing essential corrections, preferable improvements, and unresolved limitations.
A record of files reviewed, information unavailable, and questions that cannot be resolved from the supplied material.
Transparent scope
When analysis execution is requested, feasibility, software, data sensitivity, reproducibility materials, and deliverables require a separate written scope.
Start with the technical question
Provide the study stage, design, main outcome, principal concern, available files, and desired timeline. Do not upload identifiable or highly sensitive data.